Bone Abstracts

Apart from analyses of well-known correlates of age-related hip fracture risk, such as low BMD, impaired external geometry and deteriorated micro-architecture, there is increasing interest to elucidate nano-structural determinants of fracture risk at the bone mineralized matrix level.In this study we analyzed cortical bone specimens of the femoral neck region in five elderly women who sustained hip fracture and in four healthy women of corresponding age....

In sharp contrast to the great interest in morphology of the proximal femur in aged individuals, there is a paucity of studies in children. To date, a comprehensive quantitative analysis of trabecular micro-architecture in various biomechanically relevant subregions of the immature proximal femur has been lacking. The aim of this study was to characterize postnatal development of trabecular bone in various regions of the human proximal femur. The study sample was comprised of ...

Hepatic osteodystrophy is an important complication of chronic liver disease associated with fractures resulting in pain, deformity and immobility. The aim of the study was to examine association of severity of alcoholic liver cirrhosis with areal bone mineral density (BMD) and to estimate bone geometric strength of the proximal femur in those patinets. The study included 27 male patients with alcoholic liver cirrhosis and control group of 36 healthy patients. Laboratory testi...

Bone remodeling is the key process in bone structural reorganization, and its alterations lead to changes in bone mechanical strength. Since osteons reflect different bone remodeling patterns, we hypothesize that the femoral cortex of females with miscellaneous age, disease, and treatment conditions will display distinct osteonal morphology and osteocyte lacunar numbers along with different mechanical properties.The specimens used in this study were coll...